Intraoral Gavage of Second-Generation Probiotic Lactobacillus Reuteri Releasing IFN-β (LR-IFN-β) Mitigates Intestinal Irradiation Toxicity and Improves Survival During Whole Abdomen Irradiation (WAI)

D.F. Hamade, J.S. Greenberger,M. Epperly,R. Fisher, W. Hou, D. Shields, J.P. van Pijkeren, A. Mukherjee,J. Yu, B. Leibowitz,A. Vlad,L. Coffman,H. Wang,M.S.S. Huq,L. Coffman, C.J. Rogers

International journal of radiation oncology, biology, physics（2023）

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摘要

LR-IFN-β is both a feasible and effective radiation mitigator that could potentially improve the management of ovarian cancer patients. Furthermore, the subsequent addition of platinum/taxane-based chemotherapy to the combination of WAI and LR-IFN-β should reduce tumor volume while protecting the intestine and thus improve overall survival in ovarian cancer patients.

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关键词

mitigates intestinal irradiation toxicity,whole abdomen irradiation,intraoral gavage,second-generation,lr-ifn

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