The Effects of Glypican-3 Deficiency on Radiosensitivity in Liver Cancer Cells

J.Y. Chung,W. Lee,D. Nambiar, S. Fayn,P.L. Choyke,F.E. Escorcia

International journal of radiation oncology, biology, physics（2023）

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摘要

Knockout lines of HepG2 and Hep3B exhibited decreased cell proliferation, migration, and in vivo tumor growth compared to wildtype. GPC-3 deficiency was associated with increased sensitivity to radiation therapy. Studies identifying the pathways through which this radiosensitivity is mediated are ongoing.

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关键词

radiosensitivity,cancer cells,liver,deficiency

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