Long-Term Follow-Up Analysis of NRG Oncology RTOG 0415: A Randomized Phase III Non-Inferiority Study Comparing Two Fractionation Schedules in Patients with Favorable-Risk Prostate Cancer

W.R. Lee,J.J. Dignam,M. Amin,D.W. Bruner,D. Low, G.P. Swanson, A.B. Shah, D.P. D'Souza,J.M. Michalski, I. Dayes, S.A. Seaward,W.A. Hall,P.L. Nguyen,T.M. Pisansky,S.L. Faria,Y. Chen, J. Rodgers,H.M. Sandler

International journal of radiation oncology, biology, physics（2023）

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摘要

In men with favorable-risk prostate cancer, long-term disease-free survival is non-inferior with 70 Gy in 28 fractions compared to 73.8 Gy in 41 fractions. The risk of BR is reduced with moderate hypofractionation. No differences in late Grade ≥3 GI/GU toxicity were observed between the arms. (ClinicalTrials.gov identifier: NCT00331773).

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关键词

nrg oncology rtog,prostate cancer,fractionation schedules,long-term,non-inferiority,favorable-risk

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