Investigating Dosimetry and Imaging Biomarkers for Prediction of Major Adverse Cardiac Events Following Locally Advanced Non-Small Cell Lung Cancer Radiotherapy

H.J. No, N.J. Park, F.B. Guo, N. Kastelowitz, J.M. Snyder, J.W. Rhee, D.E. Clark,A.L. Chin,L. Vitzthum,K.C. Horst, E.J. Moding,B.W. Loo,M. Diehn,M.S. Binkley

International journal of radiation oncology, biology, physics（2023）

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摘要

RT-induced MACE occurs in >20% of those undergoing thoracic RT in a median time of <2 years. We validate significant associations between TotalLeft RT dose and MACE and establish CAC as a predictive risk factor. These findings may serve to inform personalized RT and future cardiac risk in locally advanced NSCLC.

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lung cancer,major adverse cardiac events,cell lung cancer,radiotherapy,imaging biomarkers,non-small

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