Harmonizing Definitions for Progression Independent of Relapse Activity in Multiple Sclerosis: A Systematic Review.

Jannis Müller,Alessandro Cagol,Johannes Lorscheider,Charidimos Tsagkas,Pascal Benkert,Özgür Yaldizli,Jens Kuhle,Tobias Derfuss,Maria Pia Sormani,Alan Thompson,Cristina Granziera,Ludwig Kappos

JAMA neurology（2023）

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摘要

PIRA is the most frequent manifestation of disability accumulation across the full spectrum of traditional MS phenotypes, including clinically isolated syndrome and early RRMS. The harmonized definition suggested here may improve the comparability of results in current and future cohorts and data sets.

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