Microbiome profile and calprotectin levels as markers of risk of recurrent Clostridioides difficile infection.

Silvia Vázquez-Cuesta, Nuria Lozano García,Ana I Fernández,María Olmedo,Martha Kestler,Luis Alcalá,Mercedes Marín,Javier Bermejo,Francisco Fernández-Avilés Díaz,Patricia Muñoz,Emilio Bouza,Elena Reigadas

Frontiers in cellular and infection microbiology（2023）

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摘要

Calprotectin levels and abundance of microbial genera such as Fusobacterium and Prevotella in primary episodes could be useful as early markers of R-CDI. We propose a readily available model for prediction of R-CDI that can be applied at the initial CDI episode. The use of this tool could help to better tailor treatments according to the risk of R-CDI.

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关键词

calprotectin, biomarkers, C. difficile, microbiome, R-CDI, 16S rRNA, prediction model

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