The impact of female BMI on sperm DNA damage repair ability of oocytes and early embryonic development potential in intracytoplasmic sperm injection cycles.

Yuqing Jiang,Zhaoyang Shen,Jianmin Xu, Jing Zhu,Huan Wang,Wenhui Chen,Yingpu Sun,Qingling Yang

Frontiers in endocrinology（2023）

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摘要

When injected sperm with high DFI into the oocytes of overweight/obese women, resulting in lower fertilization, cleavage, and high-quality embryo rates in ICSI cycles, and the decreased early developmental potential of embryos from overweight/obese patients may be caused by the diminished capacity of oocytes to repair sperm DNA damage.

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关键词

sperm DNA fragmentation index (DFI), overweight/obese, embryo development, fertilization, intracytoplasmic sperm injection

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