Exploring the mechanism of metformin action in Alzheimer's disease and type 2 diabetes based on network pharmacology, molecular docking, and molecular dynamic simulation.

Therapeutic advances in endocrinology and metabolism(2023)

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摘要
Metformin exerts its effects on regulating oxidative stress, gluconeogenesis and inflammation, which may be the mechanism of action of metformin to improve the common pathological features of T2D and AD.
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关键词
Alzheimer's disease, metformin, network pharmacology, molecular docking, type 2 diabetes
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