Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol.

Anna Bertolini,Vincent W Bloks,Marijn Wilmink,Eline Bos,Ivo P van de Peppel, Roos Eilers,Sake Prins,Rachel Thomas,Alain de Bruin,Henkjan Verkade,Johan W Jonker

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society（2023）

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摘要

PEG, a non-absorbable osmotic laxative, improved intestinal nutrient absorption, intestinal bile acid and xenobiotic signaling, as well as CF-related liver features. These findings highlight the potential for osmotic laxation to improve gastrointestinal complications of CF in humans.

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