Radiosynthesis, preclinical evaluation and pilot clinical PET imaging study of a 18F-labeled tracer targeting fibroblast activation protein

Lilan Fu,Jiawen Huang,Qingxing Liu,Fei Xie,Yanjiang Han,Penghui Sun,Min Cao,Yanchao Huang,Kongzhen Hu,Ganghua Tang

Bioorganic chemistry（2023）

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摘要

•18F-FAPTG as a novel radiotracer for FAP PET imaging was developed.•Compared to 18F-FAPI-42, 18F-FAPTG showed significantly lower uptake in gallbladder, with higher tumor uptake and longer tumor retention.•The pilot clinical study demonstrated the safety and feasibility of 18F-FAPTG.

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preclinical pet imaging study,radiosynthesis,tracer,f-labeled

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