Advances of Wnt/β-catenin Signaling Pathway in Lung Cancer: A review.
Alternative therapies in health and medicine(2024)
摘要
Lung cancer is currently the leading cause of cancer mortality and morbidity worldwide and greatly burdens humanity. Therefore, the prevention and treatment of lung cancer remains a serious global problem. The Wnt/β-catenin signaling pathway also regulates tumor cell growth and invasion through epithelial-mesenchymal transition and tumor stem cells. In this review, we first summarise the role of the Wnt/β-catenin signaling pathway in lung cancer, focusing on the reported links in the Wnt/β-catenin signaling pathway that are relevant to lung cancer cell line growth, cell survival, and patient prognosis. Then describe the advances in the Wnt/β-catenin signaling pathway in lung cancer therapy, the precise regulation of the Wnt/β-catenin signaling pathway, that precise regulation of the Wnt/β-catenin signaling pathway should be used to balance anti-tumor effects and adverse events.
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关键词
lung cancer,wnt/β-catenin
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