Altered intestinal barrier contributes to cognitive impairment in old mice with constipation after sevoflurane anesthesia.

Tianyun Zhao,Junming Lu,Jingwen Qin,Yanxin Chen,Ziwen Shi,Wei Wei,Peng Xiong,Daqing Ma,Xingrong Song

Frontiers in nutrition（2023）

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摘要

Aged STC mice were more vulnerable to sevoflurane anesthesia and consequently developed POCD-like behavioral changes. Our data suggest that gastrointestinal disorders including constipation may contribute to the development of POCD.

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关键词

perioperative neurocognitive dysfunction, gastrointestinal dysfunction, slow transit constipation, gut permeability, microglia

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