Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation.

Lilli Leimi,Jessica R Koski,Outi Kilpivaara,Kim Vettenranta,A Inkeri Lokki,Seppo Meri

Frontiers in immunology（2023）

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摘要

Injury to the vascular endothelium is relatively common after HSCT with different phenotypic appearances suggesting yet unidentified underlying mechanisms. Variants in complement components may be related to endotheliopathy and poor prognosis in these patients.

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关键词

hematopoietic stem cell transplantation, hematopoietic stem cell transplantation adverse effects, acute toxicity, vascular complications, complement system, endothelial damage

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