Genetic Contribution to End-Stage Cardiomyopathy Requiring Heart Transplantation.

Yuri Kim, Oddný Brattberg Gunnarsdóttir,Anissa Viveiros,Daniel Reichart,Daniel Quiat,Jon A L Willcox,Hao Zhang,Huachen Chen, Justin J Curran,Daniel H Kim,Simon Urschel,Barbara McDonough,Joshua Gorham,Steven R DePalma,Jonathan G Seidman,Christine E Seidman,Gavin Y Oudit

Circulation. Genomic and precision medicine（2023）

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摘要

Pathogenic variants and viral myocarditis were identified in 45.9% of patients with unexplained end-stage cardiomyopathy. Damaging gene variants are significantly more frequent among transplant compared with patients with ambulatory cardiomyopathy. Genetic analyses can help define cause of end-stage cardiomyopathy guide management and risk stratification of patients and family members.

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heart transplantation,genetic,end-stage

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