Differential Sensitivity of Germline and Somatic BRCA Variants to PARP Inhibitor in High-Grade Serous Ovarian Cancer.

Julie A Vendrell, Iulian O Ban, Isabelle Solassol, Patricia Audran,Simon Cabello-Aguilar,Delphine Topart,Clothilde Lindet-Bourgeois,Pierre-Emmanuel Colombo,Eric Legouffe,Véronique D'Hondt,Michel Fabbro,Jérôme Solassol

International journal of molecular sciences（2023）

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摘要

The determination of the inheritance or acquisition of and alterations could provide valuable information for improving management strategies and predicting the outcome of patients with HGSOC.

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关键词

parp inhibitor,ovarian cancer,somatic brca variants,germline,high-grade

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