Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.

Izumi Kato, Yudai Ogawa,Fumika Yakushiji,Jiro Ogura,Masaki Kobayashi,Naoya Shindo,Satoshi Ichikawa,Katsumi Maenaka, Masahiro Sakaitani

Chemical communications (Cambridge, England)（2023）

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摘要

A new compound, a derivative of 3,4,5-trimethoxy--phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects , indicating high potential as a therapeutic drug for Parkinson's disease.

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new neuroprotective compound,parkinsons,beneficial effects,neuronal cells,mptp-administered

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