Polygenic scores of subcortical brain volumes as possible modulators of treatment response in depression

Vincenzo Oliva, Alfonso Martone, Giuseppe Fanelli,Katharina Domschke,Alessandra Minelli,Massimo Gennarelli,Paolo Martini,Marco Bortolomasi,Eduard Maron,Alessio Squassina,Claudia Pisanu,Siegfried Kasper,Joseph Zohar,Daniel Souery,Stuart Montgomery,Diego Albani,Gianluigi Forloni,Panagiotis Ferentinos,Dan Rujescu,Julien Mendlewicz

Neuroscience Applied（2024）

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摘要

A significant proportion of patients with major depressive disorder (MDD) do not experience remission after one or more pharmacological treatments. Research has explored brain structural measures, particularly hippocampal volume, as potential predictors of treatment response, as well as genetic factors.

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关键词

Major depression,Subcortical brain volumes,Polygenic scores,Treatment response,Basal ganglia,Striatum

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