Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.

Yi Liu,Hui Chen,Lanshu Xiao,Ping Dong,Yanhui Ma,Yunlan Zhou,Junyao Yang,Bingxian Bian,Guohua Xie,Lei Chen,Lisong Shen

Cellular oncology (Dordrecht)（2023）

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摘要

Our findings confer a comprehensive and mechanistic function of Notum in GC tumor sphere formation and tumorigenesis that may provide a novel and promising target for early diagnosis and clinical therapy of GC.

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关键词

Notum, Early-stage gastric cancer, Stemness features, Sox2, PI3K/AKT signaling pathway, Caffeine

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