Downregulation of NHE1 expression attenuates apoptosis of primary hippocampal neurons of an epilepsy model through the calpain-1 pathway.

Xuling Wu,Dongjun Xie,Qian Zheng,Shuang Peng,Ying Liu,Pengfei Ma,Lan Ye,Xiangang Mo,Zhanhui Feng

Neuroscience letters（2023）

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摘要

These results demonstrate that NHE1 participates in the promotion of neuronal apoptosis of epilepsy model in vitro through the calpain-1 pathway. Downregulation of NHE1 expression could exert a neuroprotective effect on epilepsy.

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关键词

NHE1,Calpain-1,Epilepsy,Neuronal apoptosis

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