Bisphenol A exposure triggers endoplasmic reticulum stress pathway leading to ocular axial elongation in mice.

Junhan Chen,Shin-Ichi Ikeda,Longdan Kang,Kazuno Negishi,Kazuo Tsubota,Toshihide Kurihara

Frontiers in medicine（2023）

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摘要

BPA controlled axial elongation during myopia development in a mouse model by inducing scleral ER stress and activation of the PERK/ATF6 pathway. 4-PBA eye drops as ER stress inhibitor suppressed BPA-induced myopia development.

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关键词

bisphenol A, endoplasmic reticulum stress, ATF6, PERK, sclera, myopia

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