Genetic Characterization of the H Gene of MeV Strains (H1, B3, and D4) Recently Circulated in Iran for Improving the Molecular Measles Surveillance in the National Measles Lab.

Raziyeh Zareh-Khoshchehreh,Vahid Salimi, Ghazal Sadat Fatemi Nasab,Maryam Naseri, Fatemeh Adjami Nezhad Fard,Talat Mokhtari Azad

Iranian journal of public health(2023)

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摘要
Mutations were investigated in the whole sequence of H protein. Moreover, the mutations that occur in the critical sites of the protein have an important effect on the pathogenicity of the virus. In this way, we were able to illustrate why genotype B3 is more transmissible than other measles genotypes and is the most important circulating genotype around the world.
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关键词
Molecular analysis, Hemagglutinin protein, Amino acid substitution, Vaccine efficacy, B3 genotype
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