β-CATENIN stabilizes HIF2 through lncRNA and inhibits intravenous immunoglobulin immunotherapy.

Chad Nakagawa, Manjunatha Kadlera Nagaraj,Juan Carlos Hernandez, Dinesh Babu Uthay Kumar,Vivek Shukla, Risa Machida,Jörg Schüttrumpf,Linda Sher,Patrizia Farci,Lopa Mishra,Stanley M Tahara,Jing-Hsiung James Ou,Keigo Machida

Frontiers in immunology（2023）

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摘要

Taken together, WNT and stemness pathways induced HIF2 of TICs via cooperating lncRNAs resulting in resistance to cancer immunotherapy. Therefore, therapeutic use of IVIG may suppress tumor recurrence through inhibition of TICs.

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关键词

hif2,intravenous immunoglobulin immunotherapy

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