Functionalization strategies of metal-organic frameworks for biomedical applications and treatment of emerging pollutants: A review

One of the representative coordination polymers, metal-organic frameworks (MOFs) material, is of hotspot interest in the multi field thanks to their unique structural characteristics and properties. As a novel hierarchical structural class, MOFs show diverse topologies, intrinsic behaviors, flexibility, etc. However, bare MOFs have less desirable biofunction, high humid sensitivity and instability in water, restraining their efficiencies in biomedical and environmental applications. Thus, a structural modification is required to address such drawbacks. Herein, we pinpoint new strategies in the synthesis and functionalization of MOFs to meet demanding requirements in in vitro tests, i.e., antibacterial face masks against corona virus infection and in wound healing and nanocarriers for drug delivery in anticancer. Regarding the treatment of wastewater containing emerging pollutants such as POPs, PFAS, and PPCPs, functionalized MOFs showed excellent performance with high efficiency and selectivity. Challenges in toxicity, vast database of clinical trials for biomedical tests and production cost can be still presented. MOFs-based composites can be, however, a bright candidate for reasonable replacement of traditional nanomaterials in biomedical and wastewater treatment applications.