Novel peptide calcitonin gene-related peptide antagonists for migraine therapy.

Patrick M Killoran,Vicky Capel,Vera D'Aloisio,Adam Schofield,Tímea Aczél,Kata Bölcskei,Zsuzsanna Helyes,Bengt von Mentzer,David A Kendall,Chris R Coxon,Gillian A Hutcheon

The Journal of pharmacy and pharmacology（2023）

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摘要

The project has demonstrated the potential of these novel small peptide CGRP antagonists, to undergo future preclinical evaluation as anti-migraine therapeutics.

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关键词

migraine, peptide, CGRP antagonist, chitosan microparticles, nasal delivery

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