Levo-tetrahydropalmatine ameliorates neuropathic pain by inhibiting the activation of the Clec7a-MAPK/NF-κB-NLRP3 inflammasome axis.

Dan Wu,Ping Wang,Chunhui Zhao,Jin Su,Junhong Zhang, Wangming Ma,Yanqiong Zhang,Haiyu Xu

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

This study is the first to indicate that l-THP may exert an analgesic effect through inhibiting neuroinflammation via the Clec7a-MAPK/NF-κB-NLRP3 inflammasome axis, supporting the clinical utility of l-THP in NP therapy.

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关键词

pain,levo-tetrahydropalmatine,a-mapk,b-nlrp

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