Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

IBRO Neuroscience Reports(2023)

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摘要
VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders.
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关键词
Autism,VPA,Resveratrol,Milestones,Animal model,Morphometric parameters
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