Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping.

Karl Payne,Jill Brooks,Nikolaos Batis,Naeem Khan,Mohammed El-Asrag,Paul Nankivell,Hisham Mehanna,Graham Taylor

British journal of cancer（2023）

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摘要

We demonstrate mass cytometry allows high-plex proteomic characterisation of CTCs at single-cell resolution and identify common CTC sub-groups with potential for novel biomarker development and immune checkpoint inhibitor treatment stratification.

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关键词

Head and neck cancer,Predictive markers,Biomedicine,general,Cancer Research,Epidemiology,Molecular Medicine,Oncology,Drug Resistance

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