Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury.

Xue Hu,Xiaoyang Wan,Yuting Diao,Zhe Shen,Zhongwei Zhang,Peng Wang, Danqin Hu,Xiaojing Wang,Weiming Yan,Chaohui Yu,Xiaoping Luo,Hongwu Wang,Qin Ning

International immunopharmacology（2023）

引用 0|浏览12

暂无评分

摘要

Taken together, Fgl2 hastens the development of alcoholic liver injury by mediating PKM2 dependent aerobic glycolysis in proinflammatory macrophages. Strategies that inhibiting proinflammatory macrophage activation by silencing Fgl2 might be a potential therapeutic intervention for alcoholic liver injury.

查看译文

关键词

glycolytic reprogramming,pkm2,macrophage,liver,fibrinogen-like

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要