Association of clozapine and norclozapine levels with patient and therapy characteristics-focus on interaction with valproic acid.

Bojana Panić,Marija Jovanović,Vera Lukić,Katarina Vučićević,Branislava Miljković,Srđan Milovanović

European journal of clinical pharmacology（2023）

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摘要

The results of this study may help clinicians interpret TDM data and optimize CLZ dosing regimens, especially in patients concomitantly treated with VPA. Our results show that VPA primarily decreases NCLZ levels, while alteration of the parent drug is not statistically significant.

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关键词

Clozapine, Norclozapine, Valproate, Metabolism, Pharmacokinetic variability, Drug monitoring

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