Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning.

Laura Wiffen,Leon Gerard D'Cruz,Thomas Brown, Tim W Higenbottam,Jonathan A Bernstein, Courtney Campbell,Joseph Moellman,Debajyoti Ghosh, Clive Richardson, Wynne Weston-Davies,Anoop J Chauhan

Frontiers in immunology(2023)

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摘要
Distinct immunological fingerprints from serum biomarkers exist within different severity classes of COVID-19, and harnessing them using machine learning enabled the development of clinically useful triage and prognostic tools. Complement-mediated lung injury plays a key role in COVID-19 pneumonia, and preliminary results hint at the usefulness of a C5 inhibitor in COVID-19 recovery.
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pneumonia,distinct immunological profiles,clinical severity classes,risk stratification
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