Low-intensity ultrasound combined with arsenic trioxide induced apoptosis of glioma via EGFR/AKT/mTOR.

Yi Fang,Zhiqun Bai,Jibin Cao,Gaosen Zhang,Xiang Li, Shufeng Li,Yudie Yan, Peirong Gao, Xiangkai Kong,Zhen Zhang

Life sciences（2023）

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摘要

This study showed that LIUS enables ATO to exert anti-glioma effects at a safe dose by inhibiting the activation of EGFR and the downstream AKT/mTOR pathway to regulate apoptosis. LIUS in combination with ATO is a promising novel method for treating glioma and could improve patient prognosis.

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关键词

Low-intensity ultrasound,Arsenic trioxide,Glioma,EGFR,Apoptosis

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