Boosting NAD: An opportunity for metabolic reprogramming of Th17 cells in psoriatic disease.
Cell reports. Medicine(2023)
摘要
Metabolic reprogramming of CD4 T cells has become an opportunity for adjunctive therapies. Here, Han et al. show that boosting NAD blunts systemic Th17 responses and increases antioxidant pathways through arginine and fumarate-mediated activation of NRF2 transcription factor.
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关键词
th17 cells,metabolic reprogramming,nad
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