Molecular architecture of TMEM63 mechanosensitive ion channels

Jed T. Syrenne, Parshuram J. Sonawane,Swetha E. Murthy

Cell calcium（2023）

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摘要

Novel Architecture of TMEM63: Deposited EMDB maps for OSCA1.1, EMD-34,209, and hTMEM63A, EMD-34,214, are shown. Red glows indicate regions of detected lipids that are proposed to affect the gating of these channels.Image, graphical abstract

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关键词

Mechanosensation,Lipid modulation,OSCA/TMEM63,Ion channels

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