The Relationship Between Residential Mobility and Mortality Following Acute Myocardial Infarction

Background: The extent to which residential mobility is associated with declining health among disease -specific populations, such as survivors of acute myocardial infarction (AMI), remains unknown. Methods: This prospective cohort study consisted of 3377 patients followed from index AMI (December 1, 1999 to March 30, 2003) to death or the last available follow-up date (March 30, 2020) in Ontario, Canada. Each residential postal code move from a patient's sentinel AMI event was tracked. Time -varying Cox proportional hazards examined the associated impact of each residential postal code move on mortality after adjusting for age, sex, baseline socioeconomic, psychosocial factors, changes in neighbourhood income level from each residential move, preexisting cardiovascular and noncardiovascular illnesses, and rural residence. All models evaluated death and longterm care institutionalisation as competing risks to distinguish mortality from other end -of -life destination outcomes among communitydwelling populations. Results: The study sample included 3369 patients with 1828 (54.3%) having at least 1 residential move throughout the study; 86.5% of patients either died in the community or moved from a community dwelling into a long-term care facility as an end -of -life destination. When adjusted for baseline factors and changing neighbourhood socioeconomic status over time, each residential move was associated with a 12% higher rate of death (adjusted hazard ratio [HR] 1.12, 95% confidence interval [CI] 1.05-1.19; P < 0.001) and a 26% higher rate of long-term care end -of -life institutionalisation (adjusted HR 1.26, 95% CI 1.14-1.58; P < 0.001). Conclusions: Residential mobility was associated with higher mortality after AMI. Further research is needed to better evaluate intermediary causal pathways that may explain why residential mobility is associated with end -of -life outcomes.