Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.

Changhan Chen,TingTing Xie,Yujin Zhang, Yiyan Wang,Fang Yu,Lizhen Lin,Weiru Zhang,Benjamin C Brown,Xin Zhang,Rodney E Kellems,Angelo D'Alessandro,Yang Xia

Journal of the American Society of Nephrology : JASN（2023）

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摘要

eENT1-AMPD3, two highly enriched erythrocyte purinergic components that sense hypoxia, promote eAMPK-BPGM-dependent metabolic reprogramming, O2 delivery, energy supply, and antioxidative stress capacity, which mitigates renal hypoxia and CKD progression.

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关键词

CKD, metabolism

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