Tyrosine-Mutant AAV8 Vector Mediated Efficient and Safe Gene Transfer of Pigment Epithelium-Derived Factor to Mouse Lungs.

Débora P Ferreira,Sabrina V Martini,Helena A Oliveira,Adriana L Silva,Siddharth Shenoy,Daiqin Chen,Valentina Simon,Eric Han,Natalie E West,Jung Soo Suk,Patricia R M Rocco,Hilda Petrs-Silva,Marcelo M Morales,Fernanda F Cruz

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2023）

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摘要

These findings provide a basis for further development of Y733F-AAV8-based gene therapies for safe and effective delivery of PEDF, which has anti-angiogenic, anti-inflammatory and anti-fibrotic activities and might be a promising therapy for lung inflammatory disorders.

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关键词

Gene therapy, Recombinant adeno-associated viruses serotype 8 (AAV8), Tyrosine mutant, Pigment epithelium-derived factor (PEDF)

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