Characterization of impaired beta and alpha cell function in response to an oral glucose challenge in cystic fibrosis: a cross-sectional study.

Bibi Uhre Nielsen,Inger Hee Mabuza Mathiesen,Rikke Møller,Rikke Krogh-Madsen,Terese Lea Katzenstein,Tacjana Pressler,James A M Shaw,Christian Ritz, Michael R Rickels,Darko Stefanovski,Thomas Peter Almdal,Daniel Faurholt-Jepsen

Frontiers in endocrinology（2023）

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摘要

The maximum proinsulin concentration was positively associated with nadir glucagon during the OGTT, suggesting that beta cell stress is associated with abnormal alpha cell function in adults with CF. In addition, hypoglycaemia seemed to be explained by a temporal mismatch between glucose and insulin levels rather than by an impaired glucagon response.

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关键词

cystic fibrosis, glucose tolerance, beta cells, alpha cells, hypoglycaemia

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