Targeting neoantigens to APC-surface molecules improves the immunogenicity and anti-tumor efficacy of a DNA cancer vaccine.

Marina Barrio-Calvo,Søren Vester Kofoed,Sofie Cens Holste,Anders Bundgård Sørensen,Nadia Viborg,Jens Vindahl Kringelum,Daniela Kleine-Kohlbrecher, Christian Skjødt Steenmans,Christian Bahne Thygesen,Birgitte Rønø,Stine Friis

Frontiers in immunology（2023）

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摘要

Our findings indicate the potential of the APC-targeting strategy to enhance personalized DNA cancer vaccines while acknowledging the need for further research to investigate its molecular mechanism of action and to translate the preclinical results into effective treatments for cancer patients.

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vaccine,immunogenicity,cancer,dna,apc-surface,anti-tumor

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