Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations.

Benedikt Färber, Olga Lapshyna,Axel Künstner,Michael Kohl,Thorben Sauer,Kira Bichmann,Benjamin Heckelmann,Jessica Watzelt,Kim Honselmann,Louisa Bolm,Meike Ten Winkel,Hauke Busch,Hendrik Ungefroren,Tobias Keck,Timo Gemoll,Ulrich F Wellner,Rüdiger Braun

Frontiers in oncology（2023）

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摘要

Our model system of SCDCLs identified gemcitabine-resistant subclones and provides evidence for the critical role of ITH for treatment response in PDAC. We exploited molecular differences as the basis for differential response and used these for more targeted therapy of resistant subclones.

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关键词

pancreatic cancer, intratumor heterogeneity, treatment response, gemcitabine, chemotherapy

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