Elevated Expression of Two Pore Potassium Channel THIK-1 in Alzheimer's Disease: An Inflammatory Mechanism.

Hao Tang,Yuhong Sun,Helene A Fachim,To Ka Dorcas Cheung,Gavin P Reynolds,Michael K Harte

Journal of Alzheimer's disease : JAD（2023）

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摘要

The association between THIK-1 K+ channels expression and pathology changes indicates a THIK-1-induced activation of this glial subtype in AD and PD. Therefore, specific blocks of the microglial THIK-1 K+ channels at the early stage of AD and PD may be beneficial for the patients.

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