Active inoculation with an inactivated Coxsackievirus A2 vaccine induces neutralizing antibodies and protects mice against lethal infection

Yuexia Wang,Wangquan Ji,Dong Li,Tiantian Sun,Peiyu Zhu,Junwei Li,Liang Zhang,Yu Zhang,Haiyan Yang,Shuaiyin Chen,Yuefei Jin,Guangcai Duan

Vaccine（2023）

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摘要

•This inactivated CVA2 vaccine could prevent the occurrence of severity and even death.•The inactivated CVA2 vaccine could induce high levels of neutralizing antibodies.•The inactivated CVA2 vaccine could induce cross-protection against EVA71 infection.

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关键词

Coxsackievirus A2,Hand-foot-and-mouth disease,Vaccine,Mouse model,Cross immunity

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