HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers

Luisa Roade,Mar Riveiro-Barciela,Maria Pfefferkorn,Sara Sopena,Adriana Palom,Marta Bes,Ariadna Rando-Segura,Rosario Casillas,David Tabernero,Francisco Rodríguez-Frías,Thomas Berg,Rafael Esteban,Florian van Bömmel,María Buti

JHEP Reports（2023）

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摘要

•Chronic hepatitis D with detectable HDV-RNA showed higher HBsAg and LHBs% than did that with undetectable viraemia.•In chronic hepatitis D, a trend toward higher baseline MHBs% was observed in patients who developed clinical outcomes.•A different HBsAg composition, with lower LHBs%, has been validated for HBV HBeAg-negative inactive carriers.•HBV genotype has shown a significant impact in HBsAg composition in HBV-infected patients.

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关键词

Hepatitis D,Hepatitis B,HBV,Surface antigen,HBsAg proteins,Genotype,Inactive carrier,HDV

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