Early Kinetics of Donor-Derived Cell-Free DNA After Transplantation Predicts Renal Graft Recovery and Long-Term Function.

David Cucchiari,Elena Cuadrado-Payan, Eva Gonzalez-Roca,Ignacio Revuelta, Maria Argudo,Maria José Ramirez-Bajo,Pedro Ventura-Aguiar,Jordi Rovira,Elisenda Bañon-Maneus,Enrique Montagud-Marrahi,Diana Rodriguez-Espinosa,Judit Cacho,Carolt Arana,Vicens Torregrosa,Nuria Esforzado,Frederic Cofàn,Frederic Oppenheimer,Mireia Musquera, Lluís Peri, Silvia Casas, Sham Dholakia,Eduard Palou,José M Campistol,Beatriu Bayés, Joan Antoni Puig,Fritz Diekmann

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

ddcfDNA early kinetics after transplantation reflects recovery from IRI and is associated with short-, medium- and long-term graft outcome. It may provide a more objective estimate of IRI severity in comparison with the clinical-based definitions of DGF.

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biomarkers, ddcfDNA, delayed graft function, ischemia-reperfusion injury, kidney transplantation

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