Complement proteins L-ficolin and M-ficolin are increased in axial spondyloarthritis patients and decrease after TNF-inhibitor treatment.

Clara Elbæk Mistegaard,Anne Troldborg,Annette Hansen,Steffen Thiel,Anne Grethe Jurik,Rosa M Kiil, Alice A Christiansen,Berit Schiøttz-Christensen,Oliver Hendricks,Susanne Juhl Pedersen,Inge Juul Sørensen,Mikkel Østergaard,Anne Gitte Loft

The Journal of rheumatology（2023）

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摘要

L-ficolin and M-ficolin levels are elevated in newly diagnosed axSpA patients compared with clinically relevant controls. Both L-ficolin and M-ficolin levels decrease significantly after initiating adalimumab therapy. These findings provide new insights into the inflammatory processes in axSpA and support a complement perspective in the axSpA pathogenesis.

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