Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway.

Hua Liu, Tian-Ai Zhang, Wen-Yue Zhang,Si-Rui Huang,Yue Hu, Jia Sun

Experimental neurology（2023）

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摘要

Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.

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关键词

ferroptosis,nrf2/slc7a11/gpx4,ischemia-reperfusion

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