Doxycycline PEP can induce doxycycline resistance in Klebsiella pneumoniae in a Galleria mellonella model of PEP.

Chris Kenyon,Zina Gestels,Thibaut Vanbaelen,Said Abdellati,Dorien Van Den Bossche,Irith De Baetselier,Basil Britto Xavier,Sheeba Santhini Manoharan-Basil

Frontiers in microbiology（2023）

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摘要

Doxycycline PEP can select for doxycycline, ceftriaxone and ciprofloxacin resistance in in a G. mellonella model. The emergent ramR mutations were similar to those seen in circulating strains of . These findings suggest that we need to assess the effect of doxycycline PEP on resistance induction on a broader range of bacterial species than has hitherto been the case.

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关键词

Neisseria gonorrhoeae, Klebsiella pneumoniae, doxycycline PEP, WGS, in-vivo emergence, DoxyPEP, ST220 Klebsiella pneumoniae

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