Chronic Lithium Treatment Alters NMDA and AMPA Receptor Synaptic Availability and Dendritic Spine Organization in the Rat Hippocampus.

Lucia Caffino,Giorgia Targa,Anne Stephanie Mallien,Francesca Mottarlini,Beatrice Rizzi,Judith R Homberg,Peter Gass,Fabio Fumagalli

Current neuropharmacology（2023）

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摘要

Our findings highlight a previously unknown cohesive picture of the glutamatergic implications of LiCl action that persist long after the end of its administration, revealing for the first time a profound and persistent reorganization of the glutamatergic postsynaptic density receptor composition and structure.

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