C-X-C Motif Chemokine Receptor 4-Directed Scintigraphy of Multiple Myeloma Using [99mTc]Tc-PentixaTec.

Johanna S Enke,Nic G Reitsam,Bianca Grosser,Malte Kircher,Alexander Dierks,Ralph A Bundschuh,Georgine Wienand, Luise Uhrmacher,Martin Trepel,Margret Schottelius,Constantin Lapa,Christian H Pfob

Journal of nuclear medicine : official publication, Society of Nuclear Medicine（2024）

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摘要

In multiple myeloma, C-X-C motif chemokine receptor 4 (CXCR4) plays a pivotal role in cell migration, bone marrow infiltration, and resistance to therapy ([1][1]). Recently, CXCR4-directed theranostics has increasingly aroused clinical interest in the management of multiple myeloma, as CXCR4-

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