Computational intelligence analysis of high-risk neuroblastoma patient health records reveals time to maximum response as one of the most relevant factors for outcome prediction
European journal of cancer (Oxford, England : 1990)(2023)
摘要
•Our dataset represents the largest compendium of features for neuroblastoma.•We identified the most relevant predictors of outcome and relapse\progression.•Time to max response to treatment is prognostic and stratifies high-risk patients.•Nine months is the cut-off achieving the largest separation of patients’ survival.•Max response to treatment stratifies clinically relevant subsets of patients.
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关键词
Artificial intelligence,Neuroblastoma,Maximum response to first-line treatment,Time to maximum response to first-line treatment,Random forests,Feature importance ranking
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