A neuron-specific interaction between Alzheimer's disease risk factors SORL1, APOE, and CLU.

Cell reports（2023）

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摘要

Lee et al. report that loss of the Alzheimer's disease risk factor SORL1 results in neuron-specific reduction in APOE and CLU, altered lipid homeostasis, and increased Aβ levels and phosphorylated Tau, both rescued by stabilizing retromer or enhancing autophagy.

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CP: Neuroscience

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